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ᱨᱮᱫ:Viral protease loop.png

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ᱣᱤᱠᱤᱯᱤᱰᱤᱭᱟ, ᱨᱟᱲᱟ ᱜᱮᱭᱟᱱ ᱯᱩᱛᱷᱤ ᱠᱷᱚᱱ

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ᱢᱩᱬᱩᱛ ᱠᱟᱛᱷᱟ

ᱵᱤᱵᱚᱨᱚᱱᱤ
English: The C-terminal extension only present in viral members of the PA clan of chymotrypsin-like proteases as (a) surface with loop in blue (b) secondary structure and (c) b-factor putty (wider regions indicate greater flexibility) for the structure of TEV protease C151A (1lvb). Substrate in black, active site triad in red. The final 15 amino acids (222-236) of the enzyme C-terminus are not visible in the structure as they are too flexible.
ᱢᱟᱹᱦᱤᱛ
ᱯᱷᱮᱰᱟᱛ Thomas, Shafee, (2014). "Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity". PhD Thesis. University of Cambridge.
ᱚᱱᱚᱞᱤᱭᱟᱹ Thomas Shafee

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ᱟᱲᱟᱜ ᱜᱮᱭᱟᱢ:
  • ᱦᱟᱹᱴᱤᱧᱢᱮ – ᱱᱚᱠᱚᱞ ᱞᱟᱹᱜᱤᱫ, ᱦᱟᱹᱴᱤᱧ ᱟᱨ ᱵᱷᱮᱡᱟᱭᱢᱮ ᱠᱟᱹᱢᱤ
  • ᱢᱮᱥᱟᱣᱠᱟᱛᱢᱮ – ᱠᱟᱹᱢᱤ ᱟᱞᱜᱟᱭ ᱞᱟᱹᱜᱤᱫ
ᱞᱟᱛᱟᱨ ᱨᱮᱭᱟᱜ ᱨᱤᱛ ᱞᱮᱠᱟᱛᱮ:
  • ᱟᱴᱨᱤᱵᱩᱥᱚᱱ – ᱟᱢ ᱠᱟᱹᱢᱤ ᱥᱚᱫᱚᱨ ᱦᱩᱭᱟᱢᱟ ᱡᱚᱠᱷᱚᱱ ᱚᱱᱚᱞᱤᱭᱟᱹ ᱟᱨᱵᱟᱝ ᱞᱟᱭᱥᱮᱸᱥᱩᱭᱟᱹ ᱫᱟᱨᱟᱭᱛᱮ ᱠᱟᱛᱷᱟ ᱨᱟᱠᱟᱵ ᱠᱷᱟᱱ (ᱢᱮᱱᱠᱷᱟᱱ ᱟᱠᱚ ᱩᱫᱩᱜᱟᱜ ᱦᱚᱨ ᱛᱮᱫᱚ ᱵᱟᱝ ᱡᱟᱦᱟᱸ ᱟᱠᱚᱠᱚ ᱜᱚᱲᱚᱣᱟᱢ ᱟᱨᱵᱟᱝ ᱟᱢᱟᱜ ᱠᱟᱹᱢᱤ ᱨᱮᱱᱟᱜ ᱵᱮᱵᱷᱟᱨ)
  • ᱦᱟᱹᱴᱤᱧ ᱱᱚᱝᱠᱟ ᱜᱮ – ᱟᱢ ᱡᱩᱫᱤ ᱠᱟᱹᱢᱤ ᱵᱚᱫᱚᱞ, ᱛᱚᱨᱡᱚᱢᱟ, ᱵᱟᱝᱠᱷᱟᱱ ᱱᱚᱣᱟ ᱠᱟᱹᱢᱤ ᱪᱮᱛᱟᱱᱨᱮ ᱱᱟᱣᱟ ᱠᱟᱹᱢᱤ ᱥᱤᱨᱡᱟᱹᱣᱮᱢ ᱛᱮᱭᱟᱨ ᱠᱷᱟᱱ, ᱛᱚᱵᱮ ᱟᱢ ᱫᱚ ᱚᱱᱟ ᱠᱟᱹᱢᱤ ᱚᱱᱟ ᱢᱤᱫ ᱞᱟᱤᱥᱮᱱᱥ ᱥᱮ ᱚᱱᱟ ᱞᱮᱠᱟᱱᱟᱜ ᱞᱟᱤᱥᱮᱱᱥ ᱨᱮᱜᱮ ᱪᱟᱞ ᱦᱩᱭᱩᱜ ᱛᱟᱢᱟ᱾

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